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KMID : 0357919820160040809
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Korean Journal of Pathology
1982 Volume.16 No. 4 p.809 ~ p.813
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Insulin Secreting Pancreatic Islet Cell Carcinoma : Histologic, Histochemical and Electron Microscopic Evaluation -Report of a case-
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강창석(姜昌錫)/Chang Suck Kang
심상인(沈相仁)/김선무(金善武)/이종무(李種武)/Sang In Shim/Sun Moo Kim/Chong Moo Lee
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Abstract
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Histochemical, light and electron microscopic studies of an insulin secreting islet cell
carcinoma are presented.
A 28-year-old female patient complained of a loss of consciousness, especially at the
fasting time, with hypoglycemia below 45㎎%. The symptom was relieved after meals.
Celiac angiography revealed abnormal proliferation of tumor vessels between the body
and tail portion of the pancreas. An operation was performed under the diagnosis of
functioning B cell tumor of the pancreatic islet.
A histological examination of hematoxylin-rosin stained sections of the surgical
specimen revealed gyriform pattern or diffuse growth pattern of the tumor cells with
vascular and perineural invasion. Histochemical studies including aldehyde fuchsin,
phosphotungstic acid hamatoxylin stain and modified Scott's stain revealed positive
reaction with the reagents that recognized normal B cells of the Langerhans islet. An
electron microscopic study revealed that this tumor consisted mainly of cells with a few,
immature beta granules. Numerous dense granules resembling lysosomes were found in
the majority of the cells. Extensive interdigitations of the cell membrane formed the
intercellular spices.
She is relatively well without hypoglycemia for 1 year after the operation.
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